Eph. 5:18-19 - "And be not drunk with wine, wherein is excess; but be filled with the Spirit; Speaking to yourselves in psalms and hymns and spiritual songs, singing and making melody in your heart to the Lord;"
Quote from John MacArthur concerning alcohol and the verse in Ephesians:
The Roman name for Dionysus is Bacchus. He is frequently pictured with nymphs and satyrs. The famous bacchanalian feasts were nothing more than drunken orgies. Among the massive ruins of the ancient Near Eastern city of Baalbek is a temple to Bacchus, the god of wine. It is covered with grapes and vines because that was the thrust of their worship.
Paul was saying to the Ephesian church, "Your background was communing with the gods in a state of drunkenness, but if you want to communicate with the true God, you need to be filled with His Spirit. If you want to be raised to the highest level of consciousness, simply enter the presence of God through the filling of the Holy Spirit."
I believe Paul is dealing with drunkenness as a religious issue because of the context of Ephesians 5:18-21. He contrasts the pagan liturgy of singing, dancing, and wild parties with true Christian liturgy, which involves speaking with "psalms and hymns and spiritual songs, singing and making melody in your heart to the Lord, giving thanks always for all things unto God and the Father in the name of our Lord Jesus Christ, submitting yourselves one to another in the fear of God" (vv. 19-21).
When Paul said, "Be not drunk with wine, in which is excess, but be filled with the Spirit," he was making a simple contrast. The Greek word for "excess" is asotia, which refers to uncontrolled dissipation or debauchery. Being controlled by alcohol is opposite to being controlled by the Spirit of God.